: Wednesday August 15th 2018 : Wednesday August 15th 2018Akiyoshi,T., It,o M., Murase,S., Miyazaki,M., Guengerich,F. P., Nakamura,K., Yamamoto,K., & Ohtani,H. (2013).
Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.
Drug Metabolism and Pharmacokinetics, 28, 411-415.
https://doi.org/10.2133/dmpk.DMPK-12-RG-134.
Atreya, R., Bülte, M., Gerlach, G. F., Goethe, R., Hornef, M. W., Köhler, H., ... Weiss,S. (2014).
Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis.
International Journal of Medical Microbiology,304, 858-867.
https://doi.org/10.1016/j.ijmm.2014.07.006
Autschbach, F., Eisold, S., Hinz, U., Zinser, S., Linnebacher, M., Giese, T., Löffler, T., Büchler, M. W., & Schmidt, J. (2005).
High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease.
Gut,54, 944-949.
Go to reference.
Borody,T. J., Leis,S., Warren,E. F., & Surace,R. (2002).
Treatment of severe Crohn's disease using antimycobacterial triple therapy--approaching a cure?
Digestive and Liver Disease,34, 29-38.
Go to reference.
Bull,T. J., McMinn,E. J., Sidi-Boumedine,K., Skull,A., Durkin,D., Neild,P., Rhodes,G., Pickup,R., & Hermon-Taylor,J. (2003).
Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease.
Journal of Clinical Microbiology,41, 2915-2923.
Go to reference.
Burisch,J.,&Munkholm,P. (2015).
The epidemiology of inflammatory bowel disease.
Scandinavian Journal of Gastroenterology,50, 942-951.
Go to reference.
Chae,Y. K., Arya,A., Chiec,L., Shah,H., Rosenberg,A., Patel,S., Raparia,K., Choi,J.,...Giles,F. (2017).
Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy?
Oncotarget,8, 100863-100898.
Go to reference.
Chamberlin,W. M., & Naser,S. A. (2006).
Integrating theories of the etiology of Crohn's disease. On the etiology of Crohn's disease: questioning the hypotheses.
Medical Science Monitor,12, RA27-33.
Go to reference.
Chamberlin,W., Ghobrial,G., Chehtane,M., & Naser,S. A. (2007).
American Journal of Gastroenterology, 102,689-691.
Go to reference.
Chaubey, K. K., Singh, S. V., Gupta, S., Singh, M., Sohal, J. S., Kumar, N., ... Dhama, K. (2017).
Mycobacterium avium subspecies paratuberculosis -an important food borne pathogen of high public health significance with special reference to India: an update.
The Veterinary Quarterly,37, 282-299.
Go to reference.
Coons, A. H.,Creech, H. J.,& Jones, R. N.(1941).
Immunological Properties of an Antibody Containing a Fluorescent Group.
Experimental Biology and Medicine,47, 200-202.
Go to reference.
Crohn, B. B., Ginzburg, L., & Oppenheimer, G. D. (1932).
Regional ileitis: A pathologic and clinical entity.
Journal of the American Medical Association,99,1323-1329.
Go to reference.
Danese,S., Fiorino,G., Mary,J. Y., Lakatos,P. L., D'Haens,G., Moja,L., D'Hoore,A.,... Colombel,J. F. (2015).
Development of Red Flags Index for Early Referral of Adults with Symptoms and Signs Suggestive of Crohn's Disease: An IOIBD Initiative.
Journal of Crohn's and Colitis,9, 601-606.
Go to reference.
Donaghy,J. A., Totton,N. L., & Rowe,M. T. (2004).
Persistence of Mycobacterium paratuberculosis during manufacture and ripening of cheddar cheese.
Applied and Environmental Microbiology,70, 4899-4905.
Go to reference.
Elsaghier,A., Prantera,C., Moreno,C., & Ivanyi,J. (1992).
Antibodies to Mycobacterium paratuberculosis-specific protein antigens in Crohn's disease.
Clinical and Experimental Immunology,90, 503-508.
Go to reference.
Eltholth,M. M., Marsh,V. R., Van Winden,S., & Guitian,F. J. (2009).
Contamination of food products with Mycobacterium avium paratuberculosis: a systematic review.
Journal of Applied Microbiology,107, 1061-1071.
Go to reference.
El-Zaatari,F. A., Naser,S. A., Hulten,K., Burch,P., & Graham,D. Y. (1999).
Characterization of Mycobacterium paratuberculosis p36 antigen and its seroreactivities in Crohn's disease.
Current Microbiology,39, 115-119.
Go to reference.
Faria,A. C., Schwarz,D. G., Carvalho,I. A., Rocha, B. B., De Carvalho,Castro,K. N., Silva,M. R., & Moreira,M. A. (2014).
Short communication: Viable Mycobacterium avium subspecies paratuberculosis in retail artisanal Coalho cheese from Northeastern Brazil.
Journal of Dairy Science,97, 4111-4114.
Go to reference.
Fidler,H. M., Thurrell,W., Johnson,N. M., Rook,G. A., & McFadden,J. J. (1994).
Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn's disease.
Gut,35, 506-510.
Go to reference.
Grant,I. R., Ball,H. J., & Rowe,M. T. (1998).
Effect of high-temperature, short-time (HTST) pasteurization on milk containing low numbers of Mycobacterium paratuberculosis.
Letters in Applied Microbiology,26, 166-170.
Go to reference.
Grant,I. R., Ball,H. J., & Rowe,M. T. (2002).
Incidence of Mycobacterium paratuberculosis in bulk raw and commercially pasteurized cows' milk from approved dairy processing establishments in the United Kingdom.
Applied and Environmental Microbiology,68, 2428-2435.
Go to reference.
Grant,I. R., Ball,H. J., Neill,S. D.,&Rowe,M. T. (1996).
Inactivation of Mycobacterium paratuberculosis in cows' milk at pasteurization temperatures.
Applied and Environmental Microbiology,62, 631-636.
Go to reference.
Greenstein,R. J., & Collins,M. T. (2004).
Emerging pathogens: is Mycobacterium avium subspecies paratuberculosis zoonotic?
The Lancet,364, 396-397.
Go to reference.
Gui,G. P., Thomas,P. R., Tizard,M. L., Lake,J., Sanderson,J. D., & Hermon-Taylor,J. (1997).
Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics.
The Journal of Antimicrobial Chemotherapy,39, 393-400.
Go to reference.
Hanley, J.A., &Lippman-Hand, A. (1983).
If Nothing Goes Wrong, Is Everything All Right?
The Journal of the American Medical Association,249, 1743-1745.
Go to reference.
Harris, N. B., & Barletta, R. G. (2001). Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine.
Clinical Microbiology Reviews,14, 489-512.
Go to reference.
Hulten,K., El-Zimaity,H. M., Karttunen, T. J., Almashhrawi,A., Schwartz,M. R., Graham,D. Y., & El-Zaatari,F. A. (2001).
Detection of Mycobacterium avium subspecies paratuberculosis in Crohn's diseased tissues byin situ hybridization.
The American Journal of Gastroenterology,96, 1529-1535.
Go to reference.
Ikonomopoulos,J., Pavlik,I., Bartos,M., Svastova,P., Ayele,W. Y.,... Gazouli,M. (2005).
Detection of Mycobacterium avium subsp. paratuberculosis in retail cheeses from Greece and the Czech Republic.
Applied and Environmental Microbiology,71, 8934-8936.
Go to reference.
Khan,I. A., Pilli,S.,Surendranath,A., Rampal,R., Chauhan,S. K., Tiwari,V., ... Ahuja,V. (2016).
Prevalence and Association of Mycobacterium avium subspecies paratuberculosis with Disease Course in Patients with Ulcero-Constrictive Ileocolonic Disease.
PLoS One,11, 1-11.
Go to reference.
Kirkwood,C. D., Wagner,J., Boniface,K., Vaughan,J., Michalski,W. P., Catto-Smith,A. G., Cameron,D. J., & Bishop,R. F. (2009).
Mycobacterium avium subspecies paratuberculosis in children with early-onset Crohn's disease.
Inflammatory Bowel Diseases,15, 1643-1655.
Go to reference.
Lee,A., Griffiths,T. A., Parab,R. S., King,R. K., Dubinsky,M. C.,... Rioux,K. P. (2011).
Association of Mycobacterium avium subspecies paratuberculosis with Crohn Disease in pediatric patients.
Journal of Pediatric Gastroenterology and Nutrition,52, 170-174.
Go to reference.
Mendoza,J. L., San-Pedro,A., Culebras,E., Cíes,R., Taxonera,C., Lana,R., Urcelay,E., de la Torre,F., Picazo,J. J., & Díaz-Rubio,M. (2010).
High prevalence of viable Mycobacterium avium subspecies paratuberculosis in Crohn's disease.
World Journal of Gastroenterology,28, 4558-4563.
Go to reference.
Naser,S. A., Ghobrial,G., Romero,C., & Valentine,J. F. (2004).
Culture of Mycobacterium avium subspecies paratuberculosis from the blood of patients with Crohn's disease.
Lancet,364, 1039-1044.
Go to reference.
Naser, S. A., Hulten, K., Shafran, I., Graham, D. Y., & El-Zaatari, F. A. (2000).
Specific seroreactivity of Crohn's disease patients against p35 and p36 antigens of M. avium subsp. paratuberculosis.
Veterinary Microbiology,77, 497-504.
Go to reference.
Naser,S. A., Sagramsingh,S. R., Naser,A. S., &Thanigachalam,S. (2014).
Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients.
World J.Gastroenterol,20,7403-15.
Go to reference.
Naser,S., Shafran,I., & El-Zaatari,F. (1999).
Mycobacterium avium subsp. paratuberculosis in Crohn's disease is serologically positive.
Clinical and Diagnostic Laboratory Immunology,6, 282.
Go to reference.
Nazareth,N., Magro,F., Machado,E., Ribeiro,T. G., Martinho,A., Rodrigues,P., Alves,R., Macedo,G. N., Gracio,D., Coelho,R., Abreu,C., Appelberg,R., Dias,C., Macedo,G., Bull,T., & Sarmento,A. (2015).
Prevalence of Mycobacterium avium subsp. paratuberculosis and Escherichia coli in blood samples from patients with inflammatory bowel disease.
Medical Microbiology and Immunology,204, 681-692.
Go to reference.
Olsen,I., Wiker,H. G., Johnson,E., Langeggen,H., & Reitan,L. J. (2001).
Elevated antibody responses in patients with Crohn's disease against a 14-kDa secreted protein purified from Mycobacterium avium subsp. paratuberculosis.
Scandinavian Journal of Immunology,53, 198-203.
Go to reference.
Ricchi,M., De Cicco,C., Kralik,P., Babak,V., Boniotti,M. B., Savi,R., ... Arrigoni,N. (2014).
Evaluation of viable Mycobacterium avium subsp. paratuberculosis in milk using peptide-mediated separation and Propidium Monoazide qPCR.
FEMS Microbiology Letters,356, 127-133.
Go to reference.
Romero, C., Hamdi, A., Valentine, J. F., & Naser, S. A. (2005).
Evaluation of surgical tissue from patients with Crohn's disease for the presence of Mycobacterium avium subspecies paratuberculosis DNA by in situ hybridization and nested polymerase chain reaction.
Inflammatory Bowel Diseases,11, 116-125.
Go to reference.
Ryan,P., Bennett,M. W., Aarons,S., Lee,G., Collins,J. K., O'Sullivan,G. C., O'Connell,J., & Shanahan,F. (2002).
PCR detection of Mycobacterium paratuberculosis in Crohn's disease granulomas isolated by laser capture microdissection.
Gut,51, 665-670.
Go to reference.
Sanderson,J. D.,Moss,M. T., Tizard,M. L., & Hermon-Taylor,J. (1992).
Mycobacterium paratuberculosis DNA in Crohn's disease tissue.
Gut,33, 890-896.
Go to reference.
Sechi, L. A., Scanu, A. M., Molicotti, P., Cannas, S., Mura, M., Dettori, G., Fadda, G., & Zanetti, S. (2005).
Detection and Isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal biopsies of patients with and without Crohn's disease in Sardinia.
The American Journal of Gastroenterology,100, 1529-1536.
Go to reference.
Selby,W., Pavli,P., Crotty,B., Florin,T., Radford-Smith,G., Gibson,P., ... Hetzel,D.(2007).
Antibiotics in Crohn's Disease Study Group. (2007) Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn's disease.
Gastroenterology,132, 2313-2319.
Go to reference.
Singh, S.,&Gopinath, K. (2011).
Mycobacterium avium subspecies Paratuberculosis and Crohn's Regional Ileitis: How Strong is Association?
Journal of Laboratory Physicians,3, 69-74.
Go to reference.
Suenaga,K., Yokoyama,Y., Nishimori,I., Sano,S., Morita,M., Okazaki,K., & Onishi,S. (1999).
Serum antibodies to Mycobacterium paratuberculosis in patients with Crohn's disease.
Digestive Diseases and Sciences,44, 1202-1207.
Go to reference.
Suenaga,K., Yokoyama,Y., Okazaki,K., & Yamamoto,Y. (1995).
Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease.
Am J Gastroenterol, 90, 76-80.
Go to reference.
Szkaradkiewicz, A., Chudzicka-Strugala, I., Zwozdziak, B., Marciniak, R., Wasilewska, A., & Drews, M. (2007).
Mycobacterium avium subsp. paratuberculosis w nieswoistych chorobach zapalnych jelit.
Przeglad Epidemiologiczny,61, 85-90.
Retrieved from
Go to reference.
Timms,V. J., Daskalopoulos,G., Mitchell,H. M., & Neilan,B.A. (2016).
The Association of Mycobacterium avium subsp. paratuberculosis with Inflammatory Bowel Disease.
PLoS One,11, 1-12.
Go to reference.
Tuci, A., Tonon, F., Castellani, L., Sartini, A., Roda, G., Marocchi, M., ... Belluzzi,A. (2011).
Fecal detection of Mycobacterium avium paratuberculosis using the IS900 DNA sequence in Crohn's disease and ulcerative colitis patients and healthy subjects.
Digestive Diseases and Sciences,56, 2957-2962.
Go to reference.
Van Kruiningen,H. J. (1999).
Lack of support for a common etiology in Johne's disease of animals and Crohn's disease in humans.
Inflamm. Bowel. Dis., 5, 183-91.
Go to reference.
Zamani, S., Zali, M. R., Aghdaei, H. A., Sechi, L. A., Niegowska, M., Caggiu, E., ... Feizabadi,M. M. (2017).
Mycobacterium avium subsp. paratuberculosis and associated risk factors for inflammatory bowel disease in Iranian patients.
Gut Pathogens,9, 1-10.
Go to reference.